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  • Title: Synergistic effect of ganciclovir and foscarnet on cytomegalovirus replication in vitro.
    Author: Manischewitz JF, Quinnan GV, Lane HC, Wittek AE.
    Journal: Antimicrob Agents Chemother; 1990 Feb; 34(2):373-5. PubMed ID: 2158278.
    Abstract:
    Ganciclovir and foscarnet possess substantial activity against cytomegalovirus. Both exhibit dose-limiting toxicity, which reduces their clinical usefulness. We demonstrated synergistic inhibition of cytomegalovirus replication in vitro by ganciclovir and foscarnet. Reduced-dose combination therapy may provide a means to treat patients with cytomegalovirus infection while reducing drug toxicity.
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