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  • Title: Synthesis, crystal structure and living cell imaging of a Cu(2+)-specific molecular probe.
    Author: Liu WY, Li HY, Zhao BX, Miao JY.
    Journal: Org Biomol Chem; 2011 Jul 07; 9(13):4802-5. PubMed ID: 21584299.
    Abstract:
    We report the development of a rhodamine chromene-based fluorescence probe to monitor the intracellular Cu(2+) level in living cells. The new fluorescent probe exhibits a fluorescence response towards Cu(2+) under physiological conditions with high sensitivity and selectivity, and facilitates the naked-eye detection of Cu(2+). The fluorescence intensity was significantly increased by about 40-fold with 10 equiv. of added Cu(2+).
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