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  • Title: Cyanines as efficient photosensitizers in photodynamic reaction: photophysical properties and in vitro photodynamic activity.
    Author: Kulbacka J, Pola A, Mosiadz D, Choromanska A, Nowak P, Kotulska M, Majkowski M, Hryniewicz-Jankowska A, Purzyc L, Saczko J.
    Journal: Biochemistry (Mosc); 2011 Apr; 76(4):473-9. PubMed ID: 21585324.
    Abstract:
    The purpose of the present study was to explore the potential application of cyanines in photodynamic treatment. The photophysical features of four cyanines (KF570, HM118, FBF-749, and ER-139) were investigated by elemental and spectral analyses. Two malignant cell lines (MCF-7/WT and MCF-7/DOX) were used to test the potential for use in the photodynamic therapy. The cytotoxic effects of these dyes were determined by the MTT assay after 4 and 24 h of incubation with the cyanine. KF570 and HM118 were irradiated with red light (630-nm filter) and FBF-749 and ER-139 with green light (435-nm filter). The results showed that the cyanine HM118 demonstrated a major phototoxic effect. It was also noted that the efficiency of photodynamic therapy was higher in the doxorubicin-resistant cell line (MCF-7/DOX).
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