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  • Title: Elevated laser flare values correlate with complicated course of anterior uveitis in patients with juvenile idiopathic arthritis.
    Author: Tappeiner C, Heinz C, Roesel M, Heiligenhaus A.
    Journal: Acta Ophthalmol; 2011 Sep; 89(6):e521-7. PubMed ID: 21586097.
    Abstract:
    PURPOSE: To evaluate the prognostic value of anterior chamber (AC) laser flare (LF) in uveitis associated with juvenile idiopathic arthritis (JIA). METHODS: Monocentre, retrospective study of 150 JIA children (girls n = 107, 71.3%) with unilateral or bilateral chronic anterior uveitis (statistical analysis of one eye per patient). LF values (KOWA FM-500), visual acuity, intraocular pressure, glaucoma treatment and uveitis complications were investigated longitudinally. RESULTS: Patients were followed up for a mean of 8.7 months (range 1-36). High LF values correlated with poor visual acuity (p < 0.0001). Patients with low LF values (LF ≤ 20 photon units per millisecond) less often required glaucoma medication (p = 0.0005) or surgery (p = 0.01) and showed a lower prevalence of cataract, band keratopathy, posterior synechiae, epiretinal membrane, optic disc oedema and glaucoma/ocular hypertension (p < 0.05, each). Baseline LF > 20 photon units per millisecond was a better prognosticator for the development of subsequent complications than baseline AC cells (p = 0.04). CONCLUSIONS: High LF values in patients with JIA uveitis are associated with poor vision and a higher prevalence of uveitis complications.
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