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  • Title: Delayed cord clamping and blood flow in the superior vena cava in preterm infants: an observational study.
    Author: Meyer MP, Mildenhall L.
    Journal: Arch Dis Child Fetal Neonatal Ed; 2012 Nov; 97(6):F484-6. PubMed ID: 21586482.
    Abstract:
    OBJECTIVE: To determine if timing of cord clamping affects blood flow in the upper body, as measured by flow in the superior vena cava (SVC). DESIGN: Observational study. SETTING: Neonatal Unit, Middlemore Hospital, Auckland, New Zealand. PATIENTS: 30 preterm infants <30 weeks' gestational age. INTERVENTION: Cord clamping was immediate in 17 infants and delayed by 30-45 s in 13. RESULTS: Infants in the two groups did not differ significantly in terms of gestational age, gender or use of antenatal steroids. Median flow in the SVC in the first 24 h was significantly higher in the group with delayed clamping (median 91 ml/kg/min; IQR 81-101) compared with 52 ml/kg/min (IQR 42-100) in the immediate clamping group (p=0.028). Fewer infants in the delayed group had low flow (1 compared with 9; p=0.017). All three infants with intraventricular haemorrhage (IVH) (of any grade) had low flow. CONCLUSIONS: Blood flow in the SVC was higher in infants where delayed cord clamping was performed. The relationship of IVH, low flow and timing of cord clamping requires further study.
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