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  • Title: Pharmacokinetics of levetiracetam in neonates with seizures.
    Author: Merhar SL, Schibler KR, Sherwin CM, Meinzen-Derr J, Shi J, Balmakund T, Vinks AA.
    Journal: J Pediatr; 2011 Jul; 159(1):152-154.e3. PubMed ID: 21592494.
    Abstract:
    The pharmacokinetics of levetiracetam were determined prospectively in 18 neonates with seizures. Neonates were found to have lower clearance, higher volume of distribution, and a longer half-life as compared with older children and adults. Mild somnolence was the only adverse effect.
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