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  • Title: [Analysis of the mechanism of the stress-protective action of delta sleep-inducing peptide].
    Author: Iukhananov RIu, Rozhanets VV, Mikhaleva II, Maĭskiĭ AI.
    Journal: Biull Eksp Biol Med; 1990 Jan; 109(1):46-7. PubMed ID: 2159352.
    Abstract:
    By RIA there were studied the contents of corticosterone, ACTH, beta-endorphin and insulin in the blood plasma, met- and leu-enkephalin in different regions of the rat brain and in the adrenal glands after a 6-hour immobilization. The stress increased the content of corticosterone, ACTH, beta-endorphin, but not insulin in the blood plasma, and the levels of met-enkephalin in the adrenal glands, but decreased the met-enkephalin contents in the striatum. The injection of DSIP (0.1 mg/kg, i/p) blocked partly the elevation of corticosterone only. The authors propose, that stress-protective action of DSIP is realized with the involvements of the hypothalamo-pituitary-adrenal gland system.
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