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  • Title: Superoxide anion production by circulating polymorphonuclear leucocytes in rheumatoid arthritis.
    Author: Cencetti A, De Martino M, Graziani E, Maddali Bongi S, Palermo C, Pavari E, Zoppi M.
    Journal: Clin Rheumatol; 1990 Mar; 9(1):51-5. PubMed ID: 2159392.
    Abstract:
    In twelve rheumatoid arthritis (RA) patients, receiving only nonsteroid anti-inflammatory therapy, superoxide anion (02-) generation by polymorphonuclear leucocytes (PMNs) was assessed by Cytochrome C reduction. The 02- production by non-activated PMNs in RA patients was significantly higher than in healthy controls. The 02- production by PMNs activated by zymosan and phorbol myristate acetate was significantly lower than in controls. PMNs from controls preincubated with rheumatoid sera generated higher 02- levels than the same PMNs incubated in normal sera.
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