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  • Title: Proton MR spectroscopy in herpes simplex encephalitis: assessment of neuronal loss.
    Author: Menon DK, Sargentoni J, Peden CJ, Bell JD, Cox IJ, Coutts GA, Baudouin C, Newman CG.
    Journal: J Comput Assist Tomogr; 1990; 14(3):449-52. PubMed ID: 2159493.
    Abstract:
    We present here the case of an 11-year-old boy with herpes simplex encephalitis diagnosed on the basis of clinical features, serology, and response to acyclovir, who relapsed after 3 weeks of therapy. In vivo proton magnetic resonance spectroscopy (1H MRS) of the brain, at 8 and 16 weeks after the onset of symptoms, showed abnormalities, most prominently a reduction in the N-acetylaspartate/choline ratio. The role of 1H MRS in assessing disease activity is discussed.
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