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  • Title: Intravitreal foscarnet for the treatment of acyclovir-resistant acute retinal necrosis caused by varicella zoster virus.
    Author: Lee MY, Kim KS, Lee WK.
    Journal: Ocul Immunol Inflamm; 2011 Jun; 19(3):212-3. PubMed ID: 21595539.
    Abstract:
    PURPOSE: To report of a case of acute retinal necrosis (ARN), successfully treated with intravitreal foscarnet. METHODS: Case report. RESULTS: A 40-year-old man diagnosed with varicella zoster virus (VZV)-induced ARN failed standard acyclovir treatment. He was treated subsequently with intravenous foscarnet, but developed acute renal failure after 1 day of treatment. All systemic anti-viral agents were discontinued, and intravitreal foscarnet was administered weekly. After 5 injections, the retinitis was dramatically improved. CONCLUSIONS: Intravitreal foscarnet was efficacious in the treatment of acyclovir-resistant ARN caused by VZV. It may be used as the sole treatment in patients with intolerance to systemic administration.
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