These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


Pubmed for Handhelds

PUBMED FOR HANDHELDS

Search MEDLINE/PubMed

  • Title: [The efficacy and safety of mismatched hematopoietic stem cell transplantation for treatment of severe aplastic anemia].
    Author: Han W, Huang XJ, Liu KY, Xu LP, Liu DH, Chen H, Zhang XH, Chen YH, Wang FR, Wang Y.
    Journal: Zhonghua Nei Ke Za Zhi; 2011 Apr; 50(4):287-90. PubMed ID: 21600145.
    Abstract:
    OBJECTIVE: To study the efficacy and safety of human leukocyte antigen (HLA) mismatched hematopoietic stem cell transplantation (HSCT) on severe aplastic anemia (SAA). METHODS: From January 2006 to May 2010, 17 patients received mismatched HSCT. HLA antigens were 3-loci-mismatched in 9 patients, 2-loci-mismatched in 8. All patients received recombinant human granulocyte colony-stimulating factor (rhG-CSF) primed bone marrow cells plus peripheral blood stem cells after modified busulfan/cyclophosphamide + antithymocyte immunoglobulin (BU/CY + ATG) conditioning regimen. RESULTS: All patients achieved full donor type engraftment. Grade III-IV graft versus host disease (GVHD) occurred in 3 patients and extensive chronic GVHD in 1. With a median following-up time of 285 (60 - 1670) d, 11 patients were alive, 9 of them had normal blood counts and the other 2 were blood transfusion independent. Six patients died of transplant-related complications. CONCLUSION: Mismatched HSCT is a feasible and safe option for SAA patients without sibling identical donors.
    [Abstract] [Full Text] [Related] [New Search]