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  • Title: AKAPs: the architectural underpinnings of local cAMP signaling.
    Author: Kritzer MD, Li J, Dodge-Kafka K, Kapiloff MS.
    Journal: J Mol Cell Cardiol; 2012 Feb; 52(2):351-8. PubMed ID: 21600214.
    Abstract:
    The cAMP-dependent protein kinase A (PKA) is targeted to specific compartments in the cardiac myocyte by A-kinase anchoring proteins (AKAPs), a diverse set of scaffold proteins that have been implicated in the regulation of excitation-contraction coupling and cardiac remodeling. AKAPs bind not only PKA, but also a large variety of structural and signaling molecules. In this review, we discuss the basic concepts underlying compartmentation of cAMP and PKA signaling, as well as a few of the individual AKAPs that have been shown to be functionally relevant in the heart. This article is part of a Special Issue entitled "Local Signaling in Myocytes".
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