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  • Title: Chemically induced hepatic cytosol from the Sprague-Dawley rat: evidence for specific binding of 2,3,7,8-tetrachlorodibenzo-p-dioxin to components kinetically distinct from the Ah receptor.
    Author: Landers JP, Birse LM, Nakai JS, Winhall MJ, Bunce NJ.
    Journal: Toxicol Lett; 1990 May; 51(3):295-302. PubMed ID: 2160139.
    Abstract:
    A series of exogenous chemicals was used as potential inducers for the hepatic Ah receptor in the Sprague-Dawley rat. 2,3,7,8-Tetrachlorodibenzo-p-dioxin, 2,2',4,4',5,5'-hexachlorobiphenyl and phenobarbital all induced an elevated level of 3H-2,3,7,8-tetrachlorodibenzo-p-dioxin specific binding, while 3,3',4,4'-tetrachloroazobenzene and trans-3,3',4,4'-tetrachlorostilbene caused a depression. Mixtures of these chemicals caused additive effects. Elevated levels of specific binding appeared to be heterologous, comprising a binding species having the normal high stability of the Ah receptor in its liganded form, and another less stable substance having a half-life of approximately 2 h at 37 degrees C.
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