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  • Title: Enzymatic synthesis of a 6-sialyl lactose analogue using a pH-responsive water-soluble polymer support.
    Author: Wang W, Li L, Jin C, Niu Y, Li S, Ma J, Li L, Liu Y, Cai L, Zhao W, Wang PG.
    Journal: Bioorg Med Chem Lett; 2011 Sep 01; 21(17):5041-4. PubMed ID: 21601456.
    Abstract:
    The Letter describes a strategy for the enzymatic synthesis of glycans based on a pH-responsive water-soluble polymer. In neutral condition, the polymer is water-soluble and convenient for in-solution enzymatic synthesis, whereas in acidic condition (pH lower than 4.0), the polymer disconnects with the product and becomes insoluble, which can be easily removed. A 6-Sialyl lactose analogue was synthesized as a model reaction using this approach.
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