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  • Title: Cri du chat syndrome after preimplantation genetic diagnosis for reciprocal translocation.
    Author: Ye Y, Luo Y, Qian Y, Xu C, Jin F.
    Journal: Fertil Steril; 2011 Jul; 96(1):e71-5. PubMed ID: 21601848.
    Abstract:
    OBJECTIVE: To report the first case of cri du chat syndrome after preimplantation genetic diagnosis (PGD) for reciprocal translocation. DESIGN: Case report. SETTING: In vitro fertilization center in a university affiliated hospital. PATIENT(S): A woman carrying a t(11;22)(q23;q11.2) translocation. INTERVENTION(S): Preimplantation genetic diagnosis was performed, and the woman became pregnant. MAIN OUTCOME MEASURE(S): Successful PGD for reciprocal translocation and diagnosis of Cri du chat syndrome for the baby. RESULT(S): A male baby was born at 36 weeks' gestation. However, the baby presented with a high-pitched, cat-like cry. Cytogenetic study revealed a rare case of cri du chat syndrome associated with t(11;22)(q23;q11.2) translocation. CONCLUSION(S): Chromosomal abnormalities, including the rare cru du chat syndrome, may occur after fluorescent in situ hybridization-based preimplantation genetic diagnosis.
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