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  • Title: Effectiveness of chlorhexidine on the disinfection of complete dentures colonised with fluconazole-resistant Candida albicans: in vitro study.
    Author: Mima EG, Pavarina AC, Vargas Fda S, Giampaolo ET, Machado AL, Vergani CE.
    Journal: Mycoses; 2011 Sep; 54(5):e506-12. PubMed ID: 21605178.
    Abstract:
    This in vitro study evaluated different concentrations of chlorhexidine (CHX) solution on the disinfection of dentures colonised with a reference (ATCC 90028) and azole-resistant (R1, R2 e R3) strains of Candida albicans. Sterile dentures were individually inoculated with one of the strains and incubated at 37 °C for 24 h. Then, each denture was immersed in sterile saline (control) or CHX (2%, 1% or 0.2%) for 10 min. Samples of serial dilutions were spread on Agar Sabouraud Dextrose and incubated at 37 °C for 48 h. The colonies were counted and the values of log(cfu ml(-1)) were analysed by Kruskal-Wallis test (P < 0.05). Dentures immersed in CHX were incubated for 7 days. For all strains, the cfu ml(-1) values of 0.2% CHX were significantly higher than those of 2% and 1% CHX. There was no difference between the cfu ml(-1) values of 2% and 1% CHX. For dentures immersed in CHX, ATCC 90028 strain showed lower cfu ml(-1) values than R2 and R3 strains. For control dentures, cfu ml(-1) values of ATCC 90028 strain were higher than those of R strains. Immersion in 2% CHX resulted in the highest number of dentures without fungal growth after 7 days. For denture disinfection, 2% CHX was the most effective concentration, and R strains were less susceptible to disinfection. Chlorhexidine is effective in disinfection of dentures contaminated with azole-resistant C. albicans.
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