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  • Title: Determinants of coronavirus MHV pathogenesis are localized to 3' portions of the genome as determined by ribonucleic acid-ribonucleic acid recombination.
    Author: Lavi E, Murray EM, Makino S, Stohlman SA, Lai MM, Weiss SR.
    Journal: Lab Invest; 1990 May; 62(5):570-8. PubMed ID: 2160561.
    Abstract:
    Recombinant viruses derived from coronaviruses mouse hepatitis virus strains JHM and A59, were used to map biologic properties of the virus to viral genes. The 3' portion (about 25%) of the viral genome, including the genes coding for all of the structural proteins, controls biologic properties such as organ tropism of the virus, pattern of the virus-induced central nervous system pathology in mice, plaque morphology, and virus yield in tissue culture.
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