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  • Title: Regulation of beta-adrenergic response in human lymphocytes: agonist induced subsensitivity.
    Author: Lee TP.
    Journal: Res Commun Chem Pathol Pharmacol; 1978 Nov; 22(2):233-42. PubMed ID: 216063.
    Abstract:
    The concentration of intracellular cAMP in lymphocytes is regulated by isoproterenol and PGE1. Preincubation of lymphocytes with isoproterenol leads to a loss of the response to beta-adrenergic agents but not to PGE1. Preincubation of lymphocytes with PGE1, however, affects the sensitivities both to isoproterenol and PGE1. A decrease of beta-adrenergic receptors was found in cells preincubated with isoproterenol but not with PGE1. Part of the abnormalities associated with PGE1-preincubated cells can be restored by treating the cells with theophylline.
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