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  • Title: Carbonic anhydrase I and II inhibition with natural products: caffeine and piperine.
    Author: Sethi KK, Sahoo SK, Pichikala JN, Suresh P.
    Journal: J Enzyme Inhib Med Chem; 2012 Feb; 27(1):97-100. PubMed ID: 21612376.
    Abstract:
    Novel chemotypes with carbonic anhydrase (CA; EC 4.2.1.1) inhibitory action, in addition to the sulphonamide and sulphamate were discovered, many of which are based on natural products. Caffeine and piperine were extracted and tested for inhibition of the human (h) cytosolic isoforms hCA I and II. The IC(50) values of caffeine against hCA I was of 55 mM, whereas that of piperine of 60 mM. The IC(50) values of caffeine and piperine against hCA II were of 2 mM. Although these are quite weak inhibitors they may constitute leads for developing tighter binding compounds.
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