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  • Title: [Formation of free radicals and DNA breaks after pulsed laser irradiation of DNA complexes with intercalating dyes].
    Author: Zhizhina GP, Moskalenko SA, Siniak VA, Shekun IuG, Iakshin MA.
    Journal: Biofizika; 1990; 35(1):47-52. PubMed ID: 2161260.
    Abstract:
    Destruction of lambda phage DNA is studied under nanosecond pulse laser irradiation (lambda = 355 nm) of DNA-dye complexes in solution at 77K (dye--acridine orange, 8-methoxypsoralen, ethidium bromide). Free radicals induced by laser radiation are found to participate in DNA sugar-phosphate chain scission. It was observed that the quantity of DNA double-strand breaks correlated with that of the free radicals and that of oxygen influenced DNA laser destruction.
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