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  • Title: Transport and metabolism of polyamines in human lymphocytes.
    Author: Colombatto S, Fasulo L, Fulgosi B, Grillo MA.
    Journal: Int J Biochem; 1990; 22(5):489-92. PubMed ID: 2161357.
    Abstract:
    1. Polyamines are taken up by human peripheral lymphocytes in a concentration, time and pH dependent manner, with an energy-dependent transport system. 2. Each polyamine inhibits the uptake of the others, with the exception of putrescine. Spermine appears to have the highest affinity for the transporter/s. 3. Inhibition by ouabain, amiloride and vanadate suggests that the transport is dependent on Na+. 4. Polyamine content inside the cells increases by ca 6 and 3 times respectively during incubation with spermidine or spermine. 5. The incorporated polyamines are partially transformed into each other.
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