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  • Title: Role of free radicals produced during the metabolism of mitomycin C in Escherichia coli inactivation.
    Author: Schiavano GF, Brandi G, Salvaggio L, Cattabeni FC, Cantoni O.
    Journal: Xenobiotica; 1990 May; 20(5):549-54. PubMed ID: 2161589.
    Abstract:
    1. The primary objective of this study was to assess whether reactive oxygen species produced during the metabolism of mitomycin C are responsible for, or contribute to, the induction of the cytotoxic response. 2. Escherichia coli wild-type and superoxide dismutase mutants were grown either anoxically or euoxically, in K medium or minimal glucose medium, and treated with mitomycin C in K medium or M9 salts. The cytotoxic response did not vary significantly between the wild-type and the SOD mutants. 3. The toxicity of mitomycin C was not affected by the hydroxyl radical scavengers, dimethyl sulphoxide or ethanol, whereas protection was afforded by thiourea. 4. It is concluded that oxygen radical species do not play a significant role in mediating mitomycin C inactivation of normally growing bacteria.
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