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  • Title: Spontaneous rosette formation in vitro under the effect of agents affecting the cyclic nucleotide system of circulating lymphocytes of normal subjects.
    Author: Kalmár L, Gergely P, Nékám K, Láng I, Petrányi G.
    Journal: Acta Med Acad Sci Hung; 1978; 35(1):21-8. PubMed ID: 216213.
    Abstract:
    Aminophylline was found to effect the early and total rosette-forming capacity of human thymus-dependent lymphocytes. This may be connected with an increase in the intracellular cyclic adenosine 3',5'-monophosphate level. Acetylcholine increases the proportion of early spontaneous rosettes, a phenomenon suggestive of a shift within the lymphocyte population toward a subpopulation of higher activity. The effect of acetylcholine is possibly mediated by an increase in the intracellular cyclic guanosine 3'-, 5'-monophosphate level. Aminophylline affects only the early rosette-forming capacity of thymus-derived lymphocytes. Levamisole has no influence on either early or total rosette-forming capacity of normal lymphocytes. The results are suggestive of definite relationships between the functional state, activity and cyclic nucleotide system of thymus-dependent lymphocytes.
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