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  • Title: Transcription factor networks in erythroid cell and megakaryocyte development.
    Author: Doré LC, Crispino JD.
    Journal: Blood; 2011 Jul 14; 118(2):231-9. PubMed ID: 21622645.
    Abstract:
    Erythroid cells and megakaryocytes are derived from a common precursor, the megakaryocyte-erythroid progenitor. Although these 2 closely related hematopoietic cell types share many transcription factors, there are several key differences in their regulatory networks that lead to differential gene expression downstream of the megakaryocyte-erythroid progenitor. With the advent of next-generation sequencing and our ability to precisely define transcription factor chromatin occupancy in vivo on a global scale, we are much closer to understanding how these 2 lineages are specified and in general how transcription factor complexes govern hematopoiesis.
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