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  • Title: Contribution of the parafascicular nucleus in the spontaneous object recognition task.
    Author: Castiblanco-Piñeros E, Quiroz-Padilla MF, Cardenas-Palacio CA, Cardenas FP.
    Journal: Neurobiol Learn Mem; 2011 Sep; 96(2):272-9. PubMed ID: 21624481.
    Abstract:
    The parafascicular (PF) nucleus, a posterior component of the intralaminar nuclei of the thalamus, is considered to be an essential structure in the feedback systems of basal ganglia-thalamo-cortical circuits critically involved in cognitive processes. The specific role played by multimodal information encoded in PF neurons in learning and memory processes is still unclear. We conducted two experiments to investigate the role of the PF in the spontaneous object recognition (SOR) task. The behavioral effects of pretraining rats with bilateral lesions of PF with N-methyl-D-aspartate (NMDA) were compared to vehicle controls. In the first experiment, rats were tested on their ability to remember the association immediately after training trials and in the second experiment after a 24h delay. Our findings provide evidence that PF lesions critically affect both SOR tests and support its role in that non-spatial form of relational memory.
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