These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


Pubmed for Handhelds

PUBMED FOR HANDHELDS

Search MEDLINE/PubMed

  • Title: Nano-Ag inhibiting action potential independent glutamatergic synaptic transmission but increasing excitability in rat CA1 pyramidal neurons.
    Author: Liu Z, Zhang T, Ren G, Yang Z.
    Journal: Nanotoxicology; 2012 Jun; 6(4):414-23. PubMed ID: 21627402.
    Abstract:
    The aim of this study was to investigate the actions of silver nanoparticles (nano-Ag) on glutamatergic synaptic transmission and excitability in hippocampal CA1 pyramidal neurons with whole cell patch technique. The amplitude of miniature excitatory postsynaptic currents (mEPSCs) was inhibited by silver nano-particles (nano-Ag) (10⁻⁵ g/ml and 10⁻⁴ g/ml), but the amplitude and frequency of spontaneous excitatory postsynaptic currents (sEPSCs) were increased by nano-Ag treatment (10⁻⁵ g/ml and 10⁻⁴ g/ml). Furthermore, nano-Ag (10⁻⁵ g/ml and 10⁻⁴ g/ml) increased the spontaneous network activity. These results provide further insights into the underlying mechanisms responsible for the effects of nano-Ag on central nervous system (CNS).
    [Abstract] [Full Text] [Related] [New Search]