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  • Title: Hyperbranched polymers versus dendrimers containing a carbosilane framework and terminal ammonium groups as antimicrobial agents.
    Author: Ortega P, Macarena Cobaleda B, Hernández-Ros JM, Fuentes-Paniagua E, Sánchez-Nieves J, Tarazona MP, Copa-Patiño JL, Soliveri J, de la Mata FJ, Gómez R.
    Journal: Org Biomol Chem; 2011 Jul 21; 9(14):5238-48. PubMed ID: 21629893.
    Abstract:
    A new family of amine- and ammonium-terminated hyperbranched polycarbosilanes (PCS) and dendrimers has been synthesized. The functionalization of a polycarbosilane matrix was carried out with peripheral allyl groups by two strategies in the case of PCS: 1) hydrosilylation of allyl amines with PCS containing terminal Si-H bonds, or 2) hydrosilylation of PCS-allyl with an aminosilane. Dendrimers with terminal amine groups were synthesized by hydrosilylation of allydimethylamine. Quaternized systems with MeI are soluble and stable in water or other protic solvent. The antibacterial properties of the ammonium-terminated hyperbranched polycarbosilanes and dendrimers have been evaluated showing that they act as potent biocides against Gram-positive and Gram-negative bacterial strains.
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