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  • Title: Genome-wide association studies (GWAS): impact on elucidating the aetiology of diabetes.
    Author: Hakonarson H, Grant SF.
    Journal: Diabetes Metab Res Rev; 2011 Oct; 27(7):685-96. PubMed ID: 21630414.
    Abstract:
    It has proven to be challenging to isolate the genes underlying the genetic components conferring susceptibility to type 1 and type 2 diabetes. Unlike previous approaches, 'genome-wide association studies' have extensively delivered on the promise of uncovering genetic determinants of complex diseases, with a number of novel disease-associated variants being largely replicated by independent groups. This review provides an overview of these recent breakthroughs in the context of type 1 and type 2 diabetes, and outlines strategies on how these findings will be applied to impact clinical care for these two highly prevalent disorders.
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