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  • Title: Tumor necrosis factor-α promoter gene polymorphisms are not associated with hepatitis C virus infection in Chinese hemodialysis patients.
    Author: Zhang X, Hu D, Zhu B, Wang C, He J, Wu J, Yu RB, Zhao WH.
    Journal: Ren Fail; 2011; 33(6):593-9. PubMed ID: 21631181.
    Abstract:
    BACKGROUND AND AIMS: The aim of this study was to investigate the possible influence of tumor necrosis factor-α (TNF-α) gene promoter polymorphisms on the hepatitis C virus (HCV) infection in Chinese hemodialysis (HD) patients. METHODS: A total of 884 HD patients from 14 HD centers in south China were investigated. The TNF-α gene promoter polymorphisms at positions 238 and 308 of the patients were detected by the polymerase chain reaction (PCR)-restriction fragment length polymorphism method. RESULTS: Among the 884 patients, 176 (19.9%) were anti-HCV (+), and 142 (80.7%) of the anti-HCV (+) patients became chronically infected. The anti-HCV (+) patients showed longer duration of HD, higher rate of blood transfusion, kidney transplantation, and dialyzer reuse, compared with the anti-HCV (-) patients. However, the distributions of TNF-α -238 and -308 alleles and genotypes had no significant differences between the anti-HCV (+) and the anti-HCV (-) patients (p > 0.05). And the frequencies of the above alleles and genotypes were also approximately equally distributed in the persistent infection and in the viral clearance HD patients (p > 0.05). CONCLUSIONS: This study did not suggest that the TNF-α -238 and -308 polymorphisms had influence on the infection of HCV in Chinese HD patients.
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