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  • Title: [Gender and health status response to long-term oxygen therapy in COPD patients].
    Author: Coleta KD, Lima DF, Tanni SE, Silveira LV, Godoy I, Godoy I.
    Journal: Arch Bronconeumol; 2011 Aug; 47(8):382-8. PubMed ID: 21632163.
    Abstract:
    INTRODUCTION: The association of gender with health status (HS) response to long-term oxygen therapy (LTOT) in very severe COPD is unclear. The aims of this study were: (1) to compare dyspnea perception and HS between male and female with very severe COPD at baseline and (2) to provide a prospective assessment of HS response to LTOT, according to gender. PATIENTS AND METHODS: Hypoxemic COPD (n = 97, age: 65.5 ± 9.6 years, 53% males) were enrolled in a prospective longitudinal study over 12 months or until death. St. George's Respiratory Questionnaire (SGRQ) and baseline dyspnea index (BDI) were assessed. RESULTS: At baseline, HS impairment and dyspnea sensation were similar between genders. After 12 months of LTOT, women presented improvement in symptom (64.1 ± 20.6 versus 40.6 ± 22.9; P < 0.0001) and total SGRQ scores. Men also showed improvement in symptoms after 12 months (62.7 ± 23.3 versus 49.6 ± 22.8; P < 0.0005); however, they presented deterioration of activity, impact and total scores during the study period, with markedly decline of activity domain (68.5 ± 20.0 versus 75.9 ± 16.9; P = 0.008). BDI did not show significant difference by gender over the study period. CONCLUSIONS: Our results show that the HS course in very severe COPD patients differs according to gender, as females show greater response longitudinally to LTOT.
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