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  • Title: Immune thrombocytopenia: no longer 'idiopathic'.
    Author: McCrae K.
    Journal: Cleve Clin J Med; 2011 Jun; 78(6):358-73. PubMed ID: 21632906.
    Abstract:
    Immune thrombocytopenia (ITP) is a common hematologic disorder. Its pathogenesis involves both accelerated platelet destruction and impaired platelet production. First-line agents are usually effective initially but do not provide long-term responses. Splenectomy remains an effective long-term therapy, as does rituximab (Rituxan) in a subset of patients. Thrombopoietic agents offer a new alternative, although their place in the overall management of ITP remains uncertain.
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