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  • Title: Evidence for one-electron oxidation of benzylpenicillin G by lactoperoxidase compounds I and II.
    Author: Metodiewa D, Dunford HB.
    Journal: Biochem Biophys Res Commun; 1990 Jun 29; 169(3):1211-6. PubMed ID: 2163632.
    Abstract:
    The ability of the widely used antibiotic benzylpenicillin G to undergo a peroxidatic oxidation to produce free radical species has been investigated using conventional spectrophotometry, rapid scan spectrophotometry and an ESR spin trapping technique. Lactoperoxidase was used as a model for a drug oxidizing system. The results of the investigation indicate a normal peroxidatic pathway of benzylpenicillin degradation which leads to superoxide radical generation.
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