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  • Title: TTF1-induced apoptosis of HepG-2 cells through a mitochondrial pathway.
    Author: Li Y, Bian L, Cui F, Li L, Zhang X.
    Journal: Oncol Rep; 2011 Sep; 26(3):651-7. PubMed ID: 21637920.
    Abstract:
    The Chinese medicinal herb Sorbaria sorbifolia, native to Changbai Mountain, can induce apoptosis in HepG-2 cells. We studied the mechanism by which 5, 2', 4'-trihydroxy-6,7, 5'-trimethoxyflavone (TTF1) isolated from acetic ether extracts of Sorbaria sorbifolia induces apoptosis in HepG-2 cells. The results showed that TTF1 both inhibited cell growth and induced apoptosis. RT-PCR and Western blot analysis showed that TTF1 treatment led to decreased transcription and protein expression of bcl-2 and an increase in bax, Cyt-c, caspase-3 and caspase-9. These results together suggest that TTF1 may induce apoptosis of HepG-2 cells through a mitochondrial pathway.
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