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  • Title: A new cytotoxic β-carboline alkaloid from Galianthe thalictroides.
    Author: Figueiredo PO, Garcez FR, Matos Mde F, Perdomo RT, Queiroz LM, Pott A, Garcez AJ, Garcez WS.
    Journal: Planta Med; 2011 Nov; 77(16):1852-4. PubMed ID: 21638245.
    Abstract:
    A cytotoxicity-guided fractionation of the roots of Galianthe thalictroides afforded a new β-carboline alkaloid, 1-(hydroxymethyl)-3-(2-hydroxypropan-2-yl)-2-(5-methoxy-9H- β-carbolin-1-yl)cyclopentanol, which exhibited strong cytotoxic activity against three human cancer cell lines (MCF-7, 786-0, and UACC62). Its structure was established on the basis of 1D- and 2D-NMR spectroscopic techniques supported by HRMS data.
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