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  • Title: Inhibition of neurotransmission by angiotensin I and II in rabbit isolated ear artery.
    Author: Rónai AZ.
    Journal: Eur J Pharmacol; 1990 Apr 25; 179(3):281-6. PubMed ID: 2163854.
    Abstract:
    Angiotensin I and II inhibited the nerve stimulation-induced pressure changes in isolated, perfused rabbit ear artery with an IC50 of 3.07 and 0.36 nM, respectively. Neither angiotensin I nor angiotensin II affected the basal pressure or the pressure changes elicited by exogenously administered norepinephrine (NE). The potency of angiotensin I was unaltered by 10(-5) M captopril, indicating that conversion by angiotensin converting enzyme (ACE) was not necessary and did not take place. [Sar1,Val5,Ala8]angiotensin II (3 x 10(-8) M) antagonized the effect of angiotensin I. These findings could have implications regarding ACE inhibitor therapy and the pathophysiology of migraine.
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