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  • Title: Cortical dihydropyridine binding sites and a behavioral syndrome in morphine-abstinent rats.
    Author: Antkiewicz-Michaluk L, Michaluk J, Romańska I, Vetulani J.
    Journal: Eur J Pharmacol; 1990 May 03; 180(1):129-35. PubMed ID: 2163863.
    Abstract:
    The density of cortical [3H]nitrendipine binding sites was elevated by over 40% in rats rendered morphine-abstinent by administration of naloxone after chronic treatment with morphine. The morphine-abstinent rats had significantly shortened response latencies in the hot-plate test. Nifedipine treatment abolished the signs of abstinence and normalized the hot-plate latencies in morphine-dependent, naloxone-treated rats. The results indicate that the symptoms of abstinence are related to a functional state of cortical dihydropyridine-sensitive calcium channels.
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