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  • Title: [Expression of platelet-derived growth factor receptor α and its ligand PDGF- A in breast cancer].
    Author: Liu DS, Zhang XJ, Chen G, Lu CF, Dong HY.
    Journal: Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi; 2011 Mar; 27(3):313-4, 316. PubMed ID: 21638928.
    Abstract:
    AIM: To investigate the potential significance of platelet-derived growth factor receptor-α (PDGFR-α) and platelet-derived growth factor A (PDGF-A) expression in mammary carcinomas, and analyze its correlation with the lymph node metastasis and the expression of PDGF-A. METHODS: Used immunohistochemistry to detect the protein expression of PDGFR-α and PDGF-A in paraffinembedded breast carcinomas. RESULTS: The expression of PDGFR-α and PDGF-A were observed in 51.7% and 61.7% in the breast carcinomas, respectively and showed an association with lymph node metastasis (P < 0. 05). A correlation was also found with the expression of PDGFR-α and PDGF-A (P<0.05). CONCLUSION: PDGFR-α is expressed in invasive breast carcinomas and is associated with biological aggressiveness.
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