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  • Title: Transcranial magnetic stimulation reveals high test-retest reliability for phosphenes but not for suppression of visual perception.
    Author: Siniatchkin M, Schlicke C, Stephani U.
    Journal: Clin Neurophysiol; 2011 Dec; 122(12):2475-81. PubMed ID: 21641863.
    Abstract:
    OBJECTIVE: To investigate test-retest reliability of visual cortical excitatory and inhibitory phenomena. METHODS: Transcranial magnetic stimulation (TMS) was applied over occipital cortex twice in 22 healthy young adults with at least a one-month interval between both measurements. The test-retest reliability of the phosphenes and TMS-induced suppression of visual perception was assessed using correlation and calculation of the repeatability coefficient. RESULTS: Both analyses revealed a high reliability for phosphenes but not for the suppression of visual perception. CONCLUSIONS: It seems likely that the phosphenes may be better used than the TMS-induced suppression of visual perception in experiments which need repeated measurements (e.g., longitudinal studies or studies with pharmacological and non-pharmacological interventions). SIGNIFICANCE: The study demonstrates a rather limited value of the TMS-induced suppression of visual perception for studies with repeated measurements.
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