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  • Title: [Cytogenetic study of mantle cell lymphoma].
    Author: Wang DM, Fan L, Fang C, Zhu DX, Dong H, Yang H, Qiu HR, Hong M, Qiao C, Xu W, Li JY.
    Journal: Zhonghua Yi Xue Yi Chuan Xue Za Zhi; 2011 Jun; 28(3):283-6. PubMed ID: 21644224.
    Abstract:
    OBJECTIVE: To explore the cytogenetic features of mantle cell lymphoma (MCL). METHODS: Bone marrow cells from 18 MCL patients with bone marrow invasion were cultured for 24 hours, then routine karyotype analysis was performed with R-banding technique. Interphase fluorescence in situ hybridization (FISH) and a panel of 5 probes, including CCND1/IgH, CEP12, D13S319, p53 gene and ATM gene, were used to investigate the cytogenetic features of the samples. RESULTS: Chromosome aberrations were found in 9 (64.3%, 9/14) patients by conventional cytogenetics (CC), 8(57.1%, 8/14) patients had the aberration of t(11; 14), 6(42.9%, 6/14) had complex aberrant karyotypes, of which 2 (14.3%, 2/14) had highly complex aberrant karyotypes. A total of 28 abnormalities were detected, among them 19 (67.9%) were structural abnormalities, the other 9 (32.1%) were numerical aberrations. The aberration of t(11; 14) was found in all 18 (100%) patients with MCL by FISH. Secondary cytogenetic aberrations were detected in 14 patients by FISH. The most common abnormality was del(11q22.3) (57.1%), the rate of aberrations for del(17p13), + 12 and del(13q14) were 42.9%, 35.7% and 21.4%, respectively. Two (14.3%) and 4 (28.6%) patients were detected to have combinations of 2 and 3 aberrations. CONCLUSION: In addition to t(11; 14), most MCL patients have other chromosome aberrations, especially complex aberrant karyotype.
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