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  • Title: Cyclic adenosine 3', 5'-monophosphate and the mechanism of action of three common anti-inflammatory drugs.
    Author: Deporter DA, Dunn CJ, Willoughby DA.
    Journal: Br J Pharmacol; 1979 Feb; 65(2):163-5. PubMed ID: 216451.
    Abstract:
    1 The effects of indomethacin, dexamethasone and colchicine on cyclic adenosine 3', 5'-monophosphate (cyclic AMP) concentration in leucocytes during a crystal-induced pleurisy in rats were studied. 2 Each of the drugs significantly increased leucocyte cyclic AMP content within 3 h of the injection of crystals. 3 By 6 h, leucocyte cyclic AMP levels returning toward control levels and could not be sustained at the higher level by an additional administration of the respective anti-inflammatory drug.
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