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  • Title: Amino acid substitution at position 95 in rabies virus matrix protein affects viral pathogenicity.
    Author: Ito N, Mita T, Shimizu K, Ito Y, Masatani T, Nakagawa K, Yamaoka S, Abe M, Okadera K, Minamoto N, Sugiyama M.
    Journal: J Vet Med Sci; 2011 Oct; 73(10):1363-6. PubMed ID: 21646750.
    Abstract:
    We previously reported that rabies virus strain CE(NiM), but not the parental Ni-CE strain, killed mice after intracerebral inoculation. CE(NiM) and Ni-CE are genetically identical except for two amino acids at positions 29 and 95 in the M protein. In this study, to identify which residue determines the pathogenicity, we examined pathogenicities of two Ni-CE mutants, CE(NiM29) and CE(NiM95), which were established by replacement of an amino acid residue at position 29 or 95 in the Ni-CE M protein with the corresponding residue of CE(NiM), respectively. We found that CE(NiM95), but not CE(NiM29), killed mice, indicating that the amino acid at position 95 in the M protein is the pathogenic determinant.
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