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  • Title: [Cytomegalovirus encephalo-myelo-radiculitis in acquired immunodeficiency syndrome].
    Author: Chimelli L, de Freitas MR, Bazin AR, Mhiri C, Scaravilli F, Gray F.
    Journal: Rev Neurol (Paris); 1990; 146(5):354-60. PubMed ID: 2164701.
    Abstract:
    A 30 year-old male, with the acquired immune deficiency syndrome (AIDS) presented with rapidly progressive flaccid paraplegia and sphincter incontinence. Cerebrospinal fluid examination showed elevated protein and pleocytosis. Death occurred 2 months after the onset of neurological signs. Post-mortem examination showed inflammatory necrotic lesions, relatively sparing the axons and predominantly involving the roots of the cord. Numerous cytomegalovirus (CMV) inclusion bodies were found in the necrotic lesions, in the subarachnoid spaces and in Schwann cells. CMV encephalitis and involvement of the 3rd cranial nerves were also observed. Only 8 well-documented clinico-pathological cases of acute CMV myeloradiculitis, which all presented as progressive cauda equina syndrome, have been reported until now in AIDS patients.
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