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  • Title: Copper-catalyzed direct thiolation of azoles with aliphatic thiols.
    Author: Zhou AX, Liu XY, Yang K, Zhao SC, Liang YM.
    Journal: Org Biomol Chem; 2011 Aug 07; 9(15):5456-62. PubMed ID: 21647519.
    Abstract:
    Cu(II)-catalyzed direct thiolation of azoles with thiols is described via intermolecular C-S bond formation/C-H functionalization under oxidative conditions. Both aryl thiols and aliphatic thiols are used as coupling partners, and furnished the thiolation products in moderate to good yields. The reaction is compatible with a wide range of heterocycles including oxazole, thiazole, imidazole and oxadiazole.
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