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  • Title: Inhibition of human lymphocyte mitogen and antigen response by a 15,000-dalton protein from feline leukemia virus.
    Author: Hebebrand LC, Olsen RG, Mathes LE, Nichols WS.
    Journal: Cancer Res; 1979 Feb; 39(2 Pt 1):443-7. PubMed ID: 216488.
    Abstract:
    Peripheral blood lymphocyte response of normal human subjects to mitogens and antigens was suppressed by a 15,000-dalton protein (p15) from a C-type feline leukemia virus. Four of six subjects were suppressed 70 to 96% when responding to concanavalin A or phytohemagglutinin in the presence of 5.0 microgram of p15. The three subjects who responded to streptokinase-streptodornase and Candida were suppressed 68 to 91% when cultured with 5.0 microgram of p15. The subviral protein did not appear to be cytotoxic at doses reported. Lymphocyte membrane studies with fluorescein isothiocyanate-concanavalin A revealed a reduction in concanavalin A-induced cap formation of 51 to 91% in the presence of the same dose of p15. These results demonstrate that in vitro immunological dysfunction in human lymphocytes can be induced by a C-type virion protein.
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