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  • Title: Beta-adrenoceptor and post-receptor components show different rates of desensitization to desipramine.
    Author: Tiong AH, Richardson JS.
    Journal: Eur J Pharmacol; 1990 Jun 12; 188(6):411-5. PubMed ID: 2164943.
    Abstract:
    Both 3-day and 15-day desipramine treatments (10 mg/kg, once daily) significantly reduced beta 1- but not beta 2-adrenoceptor and isoproterenol-stimulated adenylyl cyclase activities in rat cortical, hippocampal and amygdaloid membrane preparations. In contrast, 15-day but not 3-day desipramine treatment resulted in a significant reduction in NaF-, GppNHp- and forskolin-stimulated adenylyl cyclase activity. The results suggest that post-beta-adrenoceptor component desensitization occurs more slowly than receptor downregulation in response to desipramine.
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