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  • Title: Dual inhibition of 5-LOX and COX-2 suppresses esophageal squamous cell carcinoma.
    Author: Shi HY, Lv FJ, Zhu ST, Wang QG, Zhang ST.
    Journal: Cancer Lett; 2011 Oct 01; 309(1):19-26. PubMed ID: 21652147.
    Abstract:
    COX-2 and 5-LOX are up-regulated in ESCC. This study aims to determine the efficacy of COX-2 inhibitor, 5-LOX inhibitor and their combination on ESCC. Nimesulide can suppress cell growth and promote apoptosis, accompanied with a decrease of PGE(2) production. AA861 has the similar effect with a down-regulation of LTB(4). In animal experiment, the tumor volumes in drug-treated groups were significantly smaller with the lowest rates of Ki-67 positive cells. In conclusion, either COX-2 inhibitor or 5-LOX inhibitor can suppress ESCC. Dual inhibition of COX-2 and 5-LOX pathway may present a superior anticancer efficacy to either inhibition of COX-2 or 5-LOX alone.
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