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  • Title: The TCP4 transcription factor of Arabidopsis blocks cell division in yeast at G1→S transition.
    Author: Aggarwal P, Padmanabhan B, Bhat A, Sarvepalli K, Sadhale PP, Nath U.
    Journal: Biochem Biophys Res Commun; 2011 Jul 01; 410(2):276-81. PubMed ID: 21658370.
    Abstract:
    The TCP transcription factors control important aspects of plant development. Members of class I TCP proteins promote cell cycle by regulating genes directly involved in cell proliferation. In contrast, members of class II TCP proteins repress cell division. While it has been postulated that class II proteins induce differentiation signal, their exact role on cell cycle has not been studied. Here, we report that TCP4, a class II TCP protein from Arabidopsis that repress cell proliferation in developing leaves, inhibits cell division by blocking G1→S transition in budding yeast. Cells expressing TCP4 protein with increased transcriptional activity fail to progress beyond G1 phase. By analyzing global transcriptional status of these cells, we show that expression of a number of cell cycle genes is altered. The possible mechanism of G1→S arrest is discussed.
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