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  • Title: Virus-induced diabetes in mice: a quantitative evaluation of islet cell population by immunofluorescence technique.
    Author: Stefan Y, Malaisse-Lagae F, Yoon JW, Notkins AL, Orci L.
    Journal: Diabetologia; 1978 Nov; 15(5):395-401. PubMed ID: 216598.
    Abstract:
    The endocrine cell populations of pancreatic islets in encephalomyocarditis (EMC)-virus infected mice were assessed quanititatively by immunofluorescence using specific antisera against 4 islet hormones. A marked reduction of the volume of insulin-containing (B-) cells (up to one tenth of control values) was observed at all stages studied in the hyperglycaemic mice. This was accompanied by the inversion of the normal ratio between B- and non B-cells. The volume of the latter cell types was also modified at different time points after infection: glucagon-cells were augmented 14 days after infection; PP-cells were decreased 2--3 days and 21 days after infection; somatostatin-cells decreased to one-fourth of control values in hyperglycaemic animals 21 days after infection. The latter results suggest that non B-cells are also involved in islet reaction to virus infection.
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