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  • Title: Atomic force microscope-enabled studies of integrin-extracellular matrix interactions in vascular smooth muscle and endothelial cells.
    Author: Sun Z, Meininger GA.
    Journal: Methods Mol Biol; 2011; 736():411-24. PubMed ID: 21660741.
    Abstract:
    The interactions between cell surface integrins and extracellular matrix (ECM) play important roles in the function of vascular smooth muscle and endothelial cells. Atomic force microscopy (AFM) has emerged as a powerful tool to mechanically engage cell surface integrins through functionalized probes, and to apply mechanical forces directly to cells or to specific protein-protein receptor ligand interactions, such as integrin-ECM interactions. In the example of integrins, this approach allows more accurate evaluation of the regulation of integrin adhesive activities, and provides a unique approach to access and investigate integrin-mediated cellular mechanical responses. In addition, the AFM is also useful for the measurement of the cell topographic features and cell and cytoskeletal mechanical properties, such as stiffness/elasticity.
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