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  • Title: Cell fate plug and play: direct reprogramming and induced pluripotency.
    Author: Chambers SM, Studer L.
    Journal: Cell; 2011 Jun 10; 145(6):827-30. PubMed ID: 21663788.
    Abstract:
    Building on the discovery that MyoD expression reprograms fibroblasts into muscle, three papers (Vierbuchen et al., 2010; Ieda et al., 2010; Szabo et al., 2010) recently reported the reprogramming of fibroblasts into neurons, cardiomyocytes, and blood cell progenitors without first passing the cells through a pluripotent state. Here we discuss the advantages and challenges of harnessing this direct reprogramming method for regenerative medicine.
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